He became a household name as Dr. Mark Sloan on Grey’s Anatomy before gaining another major following as Cal Jacobs in HBO’s Euphoria. Throughout his career, Eric Dane also appeared in films including X-Men: The Last Stand, Marley & Me and Valentine’s Day, building a reputation as one of television’s most recognizable actors. After revealing his ALS diagnosis publicly, he

continued working and raising awareness about the disease, making his final months especially meaningful to his fans and family. Eric Dane died at the age of 53 on February 19, 2026, with his death certificate listing respiratory failure, with ALS as the underlying cause.